Tissue engineering and regenerative medicine have the potential to transform the way we treat the human body. However, the ability to recapitulate the 3D environment of tissues and cells remains a major bottleneck for the field. From mimicking the complex extracelluar matrix (ECM) to positioning cells in the right place at the right time, the spatiotemporal control of cells and their environment remain crucial for tissue growth. Our lab designs new materials to enable customizable and life-like tissue constructs. Via (macro)molecular design, we can control the rheological properties of hydrogels, create new resins for 3D printing, and control the cell-biomaterial interactions. Relying heavily on dynamic interactions (dynamic covalent, supramolecular), these materials have impressive control over the dynamic and temporal aspects of artificial extracellular matrices. We aim to push forward our ability to create more life-like tissue engineering constructs combining the power of macromolecular design, with cell culture, and biofabrication technologies.
 
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14.04.2022

Macromolecular design for biofabrication