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DTSTART;VALUE=DATE:20251203T164500
DTEND;VALUE=DATE:20251203T164500
UID:18864@agenda.unifr.ch
DESCRIPTION:Tissues, like other condensed-matter systems, can undergo collective\ntransformations that dramatically alter their mechanical and dynamical state.\nIn epithelial and carcinoma models, such transitions – from a jammed, solidlike\nconfiguration to a fluid-like, unjammed phase – govern the onset of\ncollective motility and invasive behaviour. In this talk, I will explore the\nphysical principles underlying these transitions and their implications for\ncancer progression. Drawing on concepts and quantitative tools from softmatter\nphysics, we investigate how cellular rearrangements, force\ntransmission, and cell-scale mechanics couple to biochemical signalling and\ngene-expression changes. These studies reveal that unjamming and tissue\nfluidification are not mere by-products of malignancy but active processes\nthat generate new mechanical and regulatory regimes. I will argue that these\nobservations support a unified physical framework in which malignant\ntransformation emerges as a non-equilibrium phase transition in living\nmatter – one where mechanics, dynamics, and signalling intertwine to define\nthe boundary between homeostasis and invasion.
SUMMARY:Phase transitions in cell tissues and the physics of cancer progression
CATEGORIES:Colloque / Congrès / Forum
LOCATION:PER 08\, 0.51\, Chemin du Musée 3\, 1700 Fribourg
URL;VALUE=URI:https://agenda.unifr.ch/e/fr/18864
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