Abstracts:
Chemotherapy one of the pillars in cancer therapy, but suffers from lack of activity, severe dose limiting side effects and resistance seriously impairing it potential. Important is to get more in the tumor and less in healthy and sensitive tissues. For this purpose nano-particles may be used as smart drug delivery devices or nanobots, which can be steered, controlled, monitored and facilitate through that optimal delivery with strong clinical outcome. Different methods will be presented and compared showing that local delivery can be impressively augmented, while side-effects are controlled. This may result in the patient in shifting the balance and irrespective of resistance produce a favorable outcome.